Coming in, it was an ugly match up on paper. It lived up to those expectations on the field.
Kaepernick combined for 218 total yards (164 passing, 54 yards rushing). He completed 10 of 16 passes for 164 and found Vernon Davis for his lone touchdown pass in the first quarter.
The 49ers got on the board first by taking their opening drive the distance of the field scoring on Gore's 19-yard run up the middle through the Jaguars' porous run defense.
The drive was aided by Bruce Miller's uncovered 43-yard reception on the second play of the drive.
They added to their lead on the second drive by scoring on Colin Kaepernick's 12-yard run to the left, his second in two weeks.
The 49ers made it a 21-0 game with a 10-play, 72-yard drive culminated by Davis' two-yard touchdown pass from Kaepernick.
San Francisco's four score came on Kaepernick's 9-yard run to the left, this time on a read-option, led by Gore's block down the right side. Davis had catches of 31 and 19 yards on the drive. The 49ers scored touchdowns on their first four possessions.
The Jaguars avoided a shutout by getting on the board with a 38-yard field goal just before the end of the half making it 28-3.
Kaepernick combined for 201 total yards and three scores in the first half. Jacksonville went three-and-out three times in the opening half.
The Jaguars scored their first touchdown of the day mid-way through the third when Chad Henne found a wide-open Mike Brown down the right side. Brown blew by corner Tramaine Brock, who nearly intercepted Henne the previous play on a Justin Blackmon's out route. Jacksonville took advantage of Gore's second lost fumble of the season and started the drive on San Francisco's 28-yard line.
The 49ers answered when Gore scored his second touchdown of the game late in the third, pushing the lead to 35-10 giving San Francisco's offense five-straight weeks of scoring 31 points or more.
Outside linebacker at Dan Skuta scored his first career touchdown after returning Marcedes Lewis' fumble forced by Patrick Willis 47 yards, making it 42-10 early in the fourth. The 42 points were a season-high. The 49ers came in leading the NFL in points scored off turnovers, upping their totals to 82 points off 16 takeaways.
During their five-game winning streak, the 49ers have scored nine touchdowns and four field goals on their 13 takeaways.
San Francisco heads into its bye week at 6-2, just one game back of the Seattle Seahawks in the NFC West.
San Francisco out-ran the Jaguars 221 to 90.
Kendall Hunter led all rushers with 84 yards on nine carries, many of which came in garbage time in the fourth quarter.
Anquan Boldin led the 49ers in receptions (4) and tied Bruce Miller with 56 receiving yards with the team lead. Davis had three catches for 52 yards.